INVESTIGATION OF THE ASSOCIATION BETWEEN pre-miR-423 AND pre-miR-608 GENE POLYMORPHISMS AND COLORECTAL CANCER IN A TURKISH POPULATION

Abstract

This study investigated the potential role of pre-miR-423 and pre-miR-608 gene polymorphisms in colorectal cancer (CRC) within the Turkish population. The study involved 100 healthy individuals with an average age of 52.6 and 100 individuals diagnosed with colorectal cancer with an average age of 56.89, comprising the patient group. Molecular analysis of blood samples from both groups was conducted using the Real-Time PCR method. The relationship between genotypes and alleles concerning the disease was examined through chi-square trend tests. The results revealed a statistically significant difference in genotype distribution for the pre-miR-423 A/C gene polymorphism between CRC patients and the control group (p=0.039). The CC genotype was more frequent in patients than in the control group, and it was found that the CC genotype increased the risk of colorectal cancer by 1.9% (OR=1.935, 95% CI: 1.031-3.632, p=0.040). However, for the pre-miR-608 C/G gene polymorphism, there was no statistically significant difference in genotype distribution between CRC patients and the control group (p=0.395). This study is the first to explore the potential association between pre-miR-423 and pre-miR-608 SNPs and CRC in the Turkish population. Further large-scale studies from different centers are necessary to validate these findings.