TOTAL PHENOL CONTENT, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF INULA VISCOSA FROM GUELMA- ALGERIA

Abstract

In the present study, phenolic, flavonoid and tannins composition as well as antioxidant and anti-inflammatory activities of methanolic extract of Inula viscosa L. aerial parts selected from Guelma-Algeria were investigated.

The total phenolic content, analyzed using Folin–Ciocalteu’s reagent, of the sample was 263.78 ± 1.23mg/g dry weight, expressed as gallic acid equivalents (GAE). The total flavonoid concentration, detected using aluminum chloride, was 86.274 ± 2.13mg quercetine quivalents (QE)/g dry weight. The total tannins content, detected using the Folin Denis reagent, was 29.59mg tannic acid/g dry weight.

Antioxidant activity was evaluated by radical scavenging ability (DPPH method), the result showed significant antioxidant activity with an IC50 value of 1.36mg/L and important anti-inflammatory activity also.

Our results of antioxidant and anti-inflammatory assays were justified and partially supported the popular usage of the tested plants. The high antioxidant activity found in the plant from Guelma and its great biomass in this region suggested that Inula viscosa is a good source of natural antioxidants and anti-inflammatory compounds which might have benefits for health.

Keywords: Inula viscosa, polyphenols, flavonoids, tannins, anti-inflammatory, antioxidant.